In the professional space:
Add Altium, KNX, pspice, LTSpice (luckily works in wine), and for us electronics/electric guys lol.
Linux is a 3rd class citizen in ANSYS simulation tools. Slow updates, old UI, etc… On Linux. Pretty much only used as a simulation node for kicking on sims from windows.
Pretty much all architecture software
Many ERP systems desktop apps
Not to mention a lot of companies use active directory for access control + sharepoint
Web apps suck, but have been very helpful in Linux compatibility in the enterprise space since the devs only have to care about 1 set of production builds.
At my work, software guys and mechatronics PLC focused guys get away with Ubuntu (saleae is great), but for electronics and mechanicals it is not even worth it to dual boot.
This is a good way to do it.
I went one smaller with the Node 304 which only can do 4 HDDs with a GPU inserted. Going used for consumer desktop CPU is the most powerful play for the money I think.
This is a good path forward OP for a pretty powerful server